Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents
نویسندگان
چکیده
منابع مشابه
Nutraceutical Approach for Preventing Obesity-Related Colorectal and Liver Carcinogenesis
Obesity and its related metabolic abnormalities, including insulin resistance, alterations in the insulin-like growth factor-1 (IGF-1)/IGF-1 receptor (IGF-1R) axis, and the state of chronic inflammation, increase the risk of colorectal cancer (CRC) and hepatocellular carcinoma (HCC). However, these findings also indicate that the metabolic disorders caused by obesity might be effective targets ...
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Chemoprevention of Colon Carcinogenesis by Organosulfur Compounds1
It has been reported that several naturally occurring and related syn thetic organosulfur compounds exert chemopreventive effects in several target organs in rodent models. The chemopreventive actions of 40 and 80% maximum tolerated doses (MTD) of organosulfur compounds, namely anethole trithione, diali) I disulfide, W-acelylcysteine, and taurine, administered in AIN-76A diet, on azoxymethane (...
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Previous work has shown a consistent fall in S-adenosyl-L-methionine (SAM) in the liver of diethylnitrosamine-initiated rats, during the development of preneoplastic lesions, in persistent nodules (PNs), and hepatocellular carcinomas. The injection of SAM into rats causes the reconstitution of the SAM pool, coupled with growth restraint, remodeling, and apoptosis of preneoplastic cells, and inh...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2016
ISSN: 1007-9327
DOI: 10.3748/wjg.v22.i1.394